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Review | Regular issue | Vol 81, No. 10, 2010, pp.2203-2228
Published online, 13th August, 2010
DOI: 10.3987/REV-10-676
Total Synthesis of Gambierol

Yuji Mori*

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan

Abstract

Gambierol is a marine polycyclic ether toxin isolated from the cultured cells of the ciguatera causative dinoflagellate Gambierdiscus toxicus. The fascinating molecular structure of gambierol, its association with ciguatera poisoning, and its potential biological activity have drawn significant attention from the synthetic community and provided a strong impetus for the development of an efficient path by which a total synthesis can be achieved. We recently accomplished the synthesis of gambierol based on an oxiranyl anion strategy. To date, four total syntheses have been reported. This review focuses on the efforts that culminated in the total synthesis of gambierol.