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Review | Regular issue | Vol 83, No. 3, 2011, pp.491-529
Published online, 7th January, 2011
DOI: 10.3987/REV-10-686
Synthesis and Biological Activity of Lamellarin Alkaloids: An Overview

Tsutomu Fukuda, Fumito Ishibashi, and Masatomo Iwao*

*Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

Lamellarins are natural products isolated from marine invertebrates having a unique heterocyclic ring system. Many of these natural products exhibit potentially useful biological activities such as antitumor and anti-HIV activities. In this review, we summarized the synthesis and biological activity of naturally occurring lamellarins and their analogues.