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Review | Regular issue | Vol 83, No. 5, 2011, pp.951-1003
Published online, 2nd February, 2011
DOI: 10.3987/REV-10-689
Sphingolipids and Glycosphingolipids — Their Synthesis and Bioactivities

Kenji Mori* and Takuya Tashiro

*Glycosphinogolipid Synthesis Group, Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Wako-shi, Saitama 351-0198, Japan

Abstract

Chemistry of sphingolipids and glycosphingolipids is discussed with main emphasis on their synthetic methods. Microbial, plant, animal and marine sphingolipids and glycosphingolipids with the following biological roles are treated in this review: (i) inducers of fruiting body formation in Basidiomycetes, (ii) water barrier and supporting material of animal epidermis, and (iii) bioregulators of medicinal interests including immunostimulants.