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Paper | Regular issue | Vol 83, No. 4, 2011, pp.827-835
Published online, 2nd March, 2011
DOI: 10.3987/COM-11-12146
Heck-Mizoroki Reaction of 4-Iodo-1H-pyrazoles

Yoshihide Usami,* Hayato Ichikawa, and Shinya Harusawa

*Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

Abstract

The Heck-Mizoroki reaction of 1-protected-4-iodo-1H-pyrazoles with various kinds of alkenes was examined and found to yield 1-protected-4-alkenyl-1H-pyrazoles. P(OEt)3 was a suitable ligand for the cross-coupling reaction, together with the trityl group that acted as an appropriate protecting group of 1H-pyrazole.