Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 83, No. 7, 2011, pp.1535-1552
Published online, 14th April, 2011
DOI: 10.3987/COM-11-12195
Synthetic Study of Carbocyclic Core of Cortistatin A, an Anti-Angiogenic Steroidal Alkaloid from Marine Sponge

Naoyuki Kotoku,* Yuji Sumii, Takeshi Hayashi, and Motomasa Kobayashi*

*Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 560-0871, Japan

Abstract

Synthesis of carbocyclic core of cortistatin A (1), a novel anti-angiogenic steroidal alkaloid from Indonesian marine sponge, was investigated. Intramolecular Heck cyclization using substrate 18 achieved construction of 7-membered B-ring structure. The presence of steric hindrance around the reaction center was found to favor endo cyclization pathway in this substrate.