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Paper | Special issue | Vol 84, No. 2, 2012, pp.1033-1044
Published online, 30th September, 2011
DOI: 10.3987/COM-11-S(P)81
Multicomponent Click Synthesis of Potentially Biologically Active Triazoles Catalysed by Copper Nanoparticles on Activated Carbon in Water

Francisco Alonso,* Yanina Moglie, Gabriel Radivoy, and Miguel Yus*

*Department of Organic Chemistry, Faculty of Sciences and Institute of Organic Synthesis (ISO), University of Alicante, P.O. Box 99, 03080 Alicante, Spain

Abstract

A variety of potentially biologically active 1,2,3-triazoles, derived from (–)-menthol, lactic acid, D-glucose, oestrone, cholesterol, and phenacetin, have been synthesised through the multicomponent alkyne-azide 1,3-dipolar cycloaddition catalysed by copper nanoparticles on activated carbon in neat water.