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Short Paper | Regular issue | Vol 83, No. 9, 2011, pp.2149-2155
Published online, 11th July, 2011
DOI: 10.3987/COM-11-12251
Cytotoxic Eunicellin-Type Diterpenes from the Soft Coral Litophyton viscudium

Tetsuo Iwagawa,* Daiki Kusatsu, Keiko Tsuha, Toshiyuki Hamada, Hiroaki Okamura, Tatsuhiko Furukawa, Shin-ichi Akiyama, Matsumi Doe, Yoshiki Morimoto, Fumihito Iwase, and Kaoru Takemura

*Department of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka Kagoshima 890-8544, Japan

Abstract

Five new eunicellin-type diterpenes were isolated from the soft coral Litophyton viscudium. The structures of the compounds were elucidated mainly on the basis of extensive spectroscopic analysis. Compounds exhibited cytotoxic activity against HL-60 with IC50 values of 4.2–50 μM.