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Paper | Regular issue | Vol 83, No. 12, 2011, pp.2823-2835
Published online, 12th October, 2011
DOI: 10.3987/COM-11-12357
Dihydroazamacrosphelides: Synthesis and Apoptosis Inducing Activities

Kenji Sugimoto, Yuta Kobayashi, Takashi Kondo, Naoki Toyooka, Hideo Nemoto, and Yuji Matsuya*

*Graduate School of Medicines and Pharmaceutical Sciences for Research, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan


Dihydroazamacrosphelides, which were aza-analogues of 3-epi macrosphelide L, were prepared according to ring-closing metathesis strategy. Their biological assay revealed that the oxidized diketo-analogues showed stronger apoptosis inducing activity than their dihydroxy precusors.