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Short Paper | Regular issue | Vol 85, No. 2, 2012, pp.421-429
Published online, 15th December, 2011
DOI: 10.3987/COM-11-12385
PEG-400-Promoted and Ultrasound Assisted Rap-Stoermer Reaction for Efficient Synthesis of Benzofuran-2-yl(carbazolyl)methanone Derivatives

Yang Li, Yan Yan, and Wentao Gao*

*Institute of Superfine Chemicals, School of Chemistry and Chemical Engineering, Bohai University, 19 Keji Road, Jinzhou 121000, China

Abstract

A facile synthesis of hitherto unreported (9-methyl-9H-carbazole-3,6-diyl)bis(benzofuran-2-yl-methanone)s (3a-f) is described, featuring the PEG-400-promoted and ultrasound-asisted Rap-Stoermer reaction of 3,6-dichloroacetyl-9-methyl-9H-carbazole (1) with a variety of salicylaldehydes as well as 2-hydroxy-1-naphthaldehyde (2) in the presence of K2CO3 as the base in acetonitrile. This procedure offers easy access to benzofuran-2-yl(carbazolyl)methanone derivatives in short reaction time and the products are achieved in good yields.