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Short Paper | Regular issue | Vol 85, No. 2, 2012, pp.431-439
Published online, 10th January, 2012
DOI: 10.3987/COM-11-12399
Synthesis of 3-Cyanopyrazoles from 3-Trifluoromethyl-pyrazoles via Direct Ammonolysis Reaction

Tao Yan, Yanhong Chen, Jia Wang, Yuyuan Xie, and Chunhao Yang*

*State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Science, 555 Zu Chong Zhi Road, Shanghai 201203, China

Abstract

A simple and green method to prepare 3-cyanopyrazoles in aqueous ammonia from easy-obtained 3-trifluoromethylpyrazoles was explored. Most substrates got acceptable yields. The hydrogen position of N1-H on cyanopyrazoles was assigned by X-ray crystal structure analysis.