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Short Paper | Regular issue | Vol 85, No. 3, 2012, pp.651-659
Published online, 19th January, 2012
DOI: 10.3987/COM-11-12400
Cytotoxic Xanthone Glycosides from Aerial Part of Centaurium spicatum

Ahmed E. Allam, Mohamed A. El-Shanawany, Enaam Y. Backheet, Alaa M. Nafady, Fumihide Takano,* and Tomihisa Ohta

*Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan

Abstract

A new xanthone glycoside, 8-hydroxy-3,5-dimethoxy-1-O-[α-L-arabinofuranosyl-(16)-β-D-glucopyranosyl]-xanthone (1) in addition to two known xanthones named 8-hydroxy-3,5-dimethoxy-1-O-β-D-glucopyranosyl-xanthone (2) and 1,8-dihydroxy-3,5-dimethoxyxanthone (methylbellidifolin) (3) were isolated from the methanol extract of aerial part of Centaurium spicatum, and tested for their cytotoxic activities against three different types of cell lines HeLa, THP-1and HL-60 cell lines. All compounds showed cytotoxicities to all cell lines, whereas showed a moderate activity against human monocytic cell line HL-60. Among three tested xanthones, the cytotoxic activity of compound 1 was stronger than those of other xanthones and the IC50 values for compound 1 were 3.22 (against THP-1), 8.67 (against HeLa) and 74.6 (against HL-60) µM, respectively.