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Paper | Regular issue | Vol 85, No. 3, 2012, pp.615-626
Published online, 28th December, 2011
DOI: 10.3987/COM-11-12405
Reusable Polymer-Supported 2,2’-Biarylpyridine-Copper Complexes for Huisgen [3+2] Cycloaddition in Water

Toshimasa Suzuka,* Yamato Kawahara, Kazumasa Ooshiro, Takuya Nagamine, Kazuhito Ogihara, and Matsutake Higa

*Department of Chemistry, Biology and Marine Sciences, Faculty of Science, University of Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan

Abstract

Polymer-supported 2,2-biarylpyridine–copper complexes were prepared and found to promote the Huisgen [3+2] cycloaddition reaction between azides and alkynes in water to give the corresponding triazoles in up to 95% isolated yield. The catalyst was recovered and reused several times without any loss in catalytic activity. ICP-AES analysis of the aqueous phase revealed barely detectable levels of copper residue.