Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 85, No. 3, 2012, pp.661-666
Published online, 6th January, 2012
DOI: 10.3987/COM-11-12408
Caulerchlorin, a Novel Chlorinated Bisindole Alkaloid with Antifungal Activity from the Chinese Green Alga Caulerpa racemosa

Ding-Quan Liu, Shui-Chun Mao,* Xiao-Qing Yu, Li-Hua Feng, and Xiao-Ping Lai

*Department of Pharmacy, Nanchang University, 461 Bayi Road, Nanchang, Jiangxi Province 330006, China


Caulerchlorin (2), a novel chlorinated bisindole alkaloid with an eight-membered cyclic ring between two indole rings incorporated directly with a chlorine atom, together with three known related metabolites, caulerpin (3), monomethyl caulerpinate (4), and caulersin (5), has been isolated from the Chinese green alga Caulerpa racemosa (Forssk.) J. Agardh. The structure of 2 was determined on the basis of extensive spectroscopic analysis. Compounds 25 were evaluated for their antifungal activity against Candida albicans (SC5314), Candida albicans (Y0109), Candida parapsilosis (ATCC 22019), Candida glabrata (537), Microsporum gypseum (Cmccfmza), Trichophyton rubrum (Cmccftla), Aspergillus fumigatus (07544), and Cryptococcus neoformans (32609), and the result showed that only compounds 2 and 4 had a moderate/weak antifungal activity against Cryptococcus neoformans (32609) with MIC80 values of 16 and 64 μg mL-1, respectively.