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Communication | Special issue | Vol 86, No. 2, 2012, pp.955-963
Published online, 23rd August, 2012
DOI: 10.3987/COM-12-S(N)97
IMPROVEMENT OF HELIX-FORMING ABILITY OF MANNOSIDE-LINKED ETHYNYLPYRIDINE OLIGOMERS CONSTRUCTED BY CONVERGENT SYNTHESIS

Hajime Abe,* Hiroki Makida, and Masahiko Inouye*

*Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan

Abstract

The improvement of helix-forming ability of α-D-mannoside-linked 2,6-pyridylene ethynylene "ethynylpyridine" oligomers was made by modification of the linker between the ethynylpyridine and mannoside moieties in the oligomers. The linker involves a triazole ring because the preparation utilizes Huisgen reaction, and the proper distance between the triazole ring and the ethynylpyridine moiety was found to be important to show strong Cotton effects.