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■ Direct Asymmetric α-Allylation of Ketones with Allylic Alcohols via Pd/Enamine Cooperative Function

Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*

*Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan

Abstract

Direct asymmetric α-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding α-allylated ketones in moderate yield and enantioselectivity.