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Communication | Special issue | Vol 86, No. 2, 2012, pp.979-983
Published online, 30th August, 2012
DOI: 10.3987/COM-12-S(N)101
Rapid Trifluoromethylation of Indole Derivatives

Ayako Miyazaki, Ryo Shimizu, Hiromichi Egami, and Mikiko Sodeoka*

*Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan


Rapid trifluoromethylation of indole derivatives was achieved using trimethylsilyltriflate as the catalyst. Good to high yields were observed within only 5 min at room temperature. This reaction system is able to provide not only the mono-trifluoromethylated products, but also the di-trifluoromethylated derivatives, because of its high reaction efficiency.