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Paper | Regular issue | Vol 85, No. 8, 2012, pp.1925-1931
Published online, 25th June, 2012
DOI: 10.3987/COM-12-12505
Aurone Constituents from the Flowers of Rosa rugosa and Their Biological Activities

Xuemei Gao, Liying Yang, Lidang Shu, Yanqiong Shen, Yinjie Zhang,* and Qiufen Hu*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China

Abstract

Three new aurones, rugaurones A–C (1-3), together with four known aurones (4-7) were isolated from the flowers of Rosa rugosa. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. Compounds 1-7 were tested for their anti-HIV-1 activity and cytotoxicities. The results showed that compound 3 has significant potential anti-HIV-1 activity, compounds 2 have high cytotoxic abilities, and other compounds also have moderate biological activities.