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Review | Regular issue | Vol 87, No. 1, 2013, pp.1-29
Published online, 7th November, 2012
DOI: 10.3987/REV-12-756
Chemical Pharma-Sciences that Incorporate Non-Covalent Bonded Interactions

Yoshimitsu Nagao*

*Graduate School of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan

Abstract

Molecular structure characteristics of organosulfur drugs and biologically active organosulfur compounds and the asymmetric Pummerer-type reactions are discussed in terms of non-covalent bonded S···X (X = O, N, S, halogens, etc.) interactions based on the data of X-ray crystallographic analysis, density functional theory (DFT) calculation, some spectroscopic analyses, and cold-spray ionization mass spectrometric (CSI-MS) analysis.