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Paper | Regular issue | Vol 85, No. 8, 2012, pp.1941-1948
Published online, 22nd June, 2012
DOI: 10.3987/COM-12-12510
Facile One-Pot Procedure for the Synthesis of 2-Aminothiazole Derivatives

Guodong Yin,* Junrui Ma, Houqiang Shi, and Qing Tao

*Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002, Hubei, China

Abstract

A facile, efficient synthesis of 2-aminothiazole derivatives by the reaction of easily available aromatic methyl ketones with thiourea/N-substituted thioureas in the presence of copper(II) bromide was developed. The reaction underwent a one-pot α-bromination/cyclization process.