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Communication | Regular issue | Vol 85, No. 8, 2012, pp.1891-1896
Published online, 28th June, 2012
DOI: 10.3987/COM-12-12522
Microwave-Assisted Synthesis of 2-Aminopyrimidines from Silica Gel-Adsorbed Propargyl Alcohols and Guanidine

Qing-Zhen Chen, Zong-Cang Ding, Yan-Li Ma, Zhen-Dong Wang, and Zhuang-ping Zhan*

*College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, 422 Siming Nanlu, Xiamen, Fujian 361005, China

Abstract

A novel methodology toward the synthesis of 2-aminopyrimidines has been developed. The silica gel adsorbed propargyl alcohols and guanidine easily give the corresponding 2-aminopyrimidines under microwave irradiation.