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Paper | Regular issue | Vol 85, No. 10, 2012, pp.2421-2436
Published online, 16th August, 2012
DOI: 10.3987/COM-12-12523
Novel Heterocyclic Derivatives of 2-Quinolinone Associated with Antibacterial and Antitumor Potencies

Hany M. Hassanin* and Somaya M. El-Edfawy

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11711, Egypt

Abstract

3-(2,2-Dichloroacetyl)-4-hydroxy-1-methyl-quinolin-2(1H)-one (2) was utilized to obtain several new quinolinones bearing imidazole, quinoxaline, 1,2,4-triazine, pyridotriazine and triazolotriazine heterocycles as substituents at position 3. Condensation of compound 2 with aminotriazine 12 afforded the iminone 14 which was subjected to annellation reactions leading to some new quinolinones fused at face [c]; viz. pyrazole, pyrimidine and benzodiazepine. Structure of the new compounds was confirmed by spectral and elemental analyses. The synthesized compounds were screened in vitro for their antimicrobial and antitumor activities.