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Review | Regular issue | Vol 85, No. 10, 2012, pp.2391-2414
Published online, 30th July, 2012
DOI: 10.3987/REV-12-745
Biological Evaluation of Pyrimidopyrimidines as Multi-Targeted Small Molecule Inhibitors and Resistance Modifying Agents

Reda Abdel-Rahman and Kamelia El-mahdy*

*Department of Chemistry, Faculty of Education, Ain Shams University, El-Maqreezy St, Roxy, Heliopolis, Cairo 11711, Egypt


This review provides detailed methods for the synthesis of pyrimidopyrimidine derivatives and their biological properties as uptake inhibitors. The main accent was put on the important findings in pyrimidopyrimidine chemistry and is useful for developing tumor growth inhibitors based on pyrimidopyrimidine.