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Short Paper | Regular issue | Vol 85, No. 10, 2012, pp.2515-2522
Published online, 10th August, 2012
DOI: 10.3987/COM-12-12542
Synthesis of Novel Trichloromethyl Substituted Azolo[1,3,5]triazines

Dmitrii V. Kalinin, Svetlana A. Kalinina, and Anton V. Dolzhenko*

*School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, Western Australia 6845, Australia

Abstract

The triazine ring bearing a trichloromethyl group was annelated to various aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of trichloroacetamidines in the reaction of aminoazoles with trichloroacetonitrile followed by the triazine ring closure with triethyl orthoformate affording therefore the titled compounds.