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Paper | Regular issue | Vol 85, No. 10, 2012, pp.2485-2490
Published online, 11th September, 2012
DOI: 10.3987/COM-12-12557
Two New Chromanone Derivatives from the Roots and Stems of Nicotiana tabacum and Their Cytotoxicity

Dingrong Mou, Wei Zhao, Tao Zhang, Lan Wan, Guangyu Yang, Yongkuan Chen, Qiufen Hu,* and Mingming Miao*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China

Abstract

Two new chromanone derivatives, tabchromones A and B (1-2), together with four known compunds (3-6) were isolated from the roots and stems of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. Compounds 1-6 were tested for their in vitro cytotoxicity against five human tumor (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines. Compound 1 showed significant inhibitory effect against SHSY5Y cell line, with IC50 values of 2.8 μM, and compounds 2-4 showed moderate activity for some selected cell lines, with IC50 values in the range of 4.8-8.0 μM.