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Review | Regular issue | Vol 85, No. 12, 2012, pp.2837-2877
Published online, 5th September, 2012
DOI: 10.3987/REV-12-748
Aziridine-2-carboxylates: Preparation, Nucleophilic Ring Opening, and Ring Expansion

Tsutomu Ishikawa*

*Graduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo, Chiba, Japan

Abstract

Preparation methods of aziridine-2-carboxylates are discussed. The chemical reactivities, focusing on ring opening by various nucleophiles and ring expansion to larger heterocycles, are also surveyed.