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Short Paper | Regular issue | Vol 87, No. 1, 2013, pp.125-131
Published online, 8th November, 2012
DOI: 10.3987/COM-12-12580
Isoaurones from the Stem of Cassia siamea and Their Anti-Tobacco Mosaic Virus (Anti-TMV) Activity

Xue-mei Gao, Li-dan Shu, Li-ying Yang, Yan-qiong Shen, Ming-zhu Cui, Xue-mei Li,* and Qiu-fen Hu*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China

Abstract

Two new isoaurones, siamaurones A and B (1-2), together with three known isoaurones (3-5) were isolated from the stems of Cassia siamea. The structures of 1-5 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques. Compounds 1-5 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. As a result, compound 2 showed high anti-TMV activity with inhibition rate of 31.8%, which is higher than that of Ningnanmycin (26.5%). Compounds 1, 3, and 5 showed modest anti-TMV activity with inhibition rate of 15.2%, 16.4%, and 12.8%, respectively.