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Short Paper | Special issue | Vol 86, No. 2, 2012, pp.1675-1688
Published online, 22nd November, 2012
DOI: 10.3987/COM-12-S(N)122
SYNTHESIS OF A LIBRARY OF 1,5,2-DITHIAZAPINE 1,1-DIOXIDES. PART 2: ROUTES TO BICYCLIC SULTAMS

Qin Zang, Salim Javed, Aihua Zhou, Chirs A. Knudtson, Danse Bi, Fatima Z. Basha, and Paul R. Hanson*

*Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., 66045-7582, U.S.A.

Abstract

The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine-1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael (“cy-click”) protocol, several additional cyclization strategies have been realized enabling access to new bicyclic sultams.