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Short Paper | Regular issue | Vol 85, No. 12, 2012, pp.3015-3019
Published online, 23rd October, 2012
DOI: 10.3987/COM-12-12589
Nigelactone, New Phthalide Glucoside from the Seeds Nigella glandulifera

Yu Feng, Yu-Ming Liu,* Qing-Hua Liu, and Ying-Jie Lei

*Department of Pharmacy Engineering, Tianjin University of Technology, No.391, Bin Shui Xi Road, Xi Qing District, Tianjin , China

Abstract

Chemical investigations of the seeds of Nigella glandulifera have resulted in the isolation of a new phthalide derivative, nigelactone (1), together with two known metabolites. Their structures were established by detailed analysis of their 1D and 2D NMR spectra and mass spectroscopic data. Nigelactone (1) possesses a rare structural skeleton found in nature.