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Paper | Regular issue | Vol 87, No. 2, 2013, pp.307-318
Published online, 6th December, 2012
DOI: 10.3987/COM-12-12594
Glycosylated Methoxy-Macrolactins from a Marine Sediment Bacterium Bacillus subtilis

Hee Jae Shin,* Fakir Shahidullah Tareq, Ji Hye Kim, Min Ah Lee, Hyi-Seung Lee, Yeon-Ju Lee, and Jong-Seok Lee

*Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science & Technology, 787, Haeanro, Ansan 426-744, Korea

Abstract

Fermentation of a bacterium Bacillus subtilis isolated from the marine sediment sample collected at Gageocho, Republic of Korea in sea water based modified Bennett’s medium followed by double ethyl acetate (EA) extraction of the supernatant, sequential fractionations and purifications afforded three new glycosylated methoxymacrolactins (13). The characterization of these compounds was achieved by various spectroscopic techniques including HRESIMS and extensive 1D and 2D NMR data analyses. The stereoconfiguration was assigned based on the chemical derivatization studies and literature data reviews. Methoxymacrolactins were found to exhibit good antimicrobial properties when tested against bacteria and fungi. But, these compounds did not display any antiplasmodial activity against Plasmodium falciparum (D10).