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Paper | Regular issue | Vol 87, No. 3, 2013, pp.583-589
Published online, 30th January, 2013
DOI: 10.3987/COM-12-12642
Aurones and Isoaurones from the Flowers of Rosa damascena and Their Biological Activities

Xue-Mei Gao, Li-Ying Yang, Xiang-Zhong Huang, Li-Dan Shu, Yan-Qiong Shen, Qiu-Fen Hu,* and Zhang-Yu Chen*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China

Abstract

One new aurone, one new isoaurone, damaurones A and B (1 and 2), and five known compounds (3-7) were isolated from the flowers of Rosa damascena. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. Compound 1 is the first naturally occurring aurone derivatives bearing an acetyl group. Compounds 1-7 were tested for their anti-HIV-1 activities and cytotoxicities. The results showed that compound 1 has significant potential anti-HIV-1 activity with therapeutic index (TI) values above 80, and showed high cytotoxicities against NB4 and MCF7 cell with IC50 values of 3.4 and 2.6 μM, respectively.