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Communication | Special issue | Vol 88, No. 1, 2014, pp.179-186
Published online, 16th July, 2013
DOI: 10.3987/COM-13-S(S)30
N,N-Bond Formation in Intramolecular Cobalt-Catalyzed [2+2+2] Cyclizations of Alkynyl-Linked Bisnitriles, and the Preparation of Annulated Pyridazines

Cuifang Cai, Megan A. Audet, and John K. Snyder*

*Department of Chemistry, Boston University, 590 Commonwealth Ave RM 474, Boston, MA 02215, U.S.A.

Abstract

Cobalt(I) catalyzed intramolecular [2 + 2 + 2] cyclization of bisnitriles linked through a central alkyne has led to a facile route to annulated pyridazines. Ring closure through N,N-bond formation allows the construction of annulated pyridazine scaffolds that can be utilized in further small molecule library syntheses.