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Review | Special issue | Vol 88, No. 1, 2014, pp.103-127
Published online, 16th July, 2013
DOI: 10.3987/REV-13-SR(S)2
Additive Effects on Asymmetric Hydrogenation of N-Heteroaromatics

Takuto Nagano, Atsuhiro Iimuro, Kenta Yamaji, Yusuke Kita, and Kazushi Mashima*

*Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan

Abstract

The multiplication of chiral information is one of the most important tasks in organic chemistry. Chiral catalysis is the most elegant way to achieve this and organic chemists developed a variety of catalytic asymmetric reaction systems, in which the addition of some chemicals effectively improves the performance of transition-metal-catalysis. In this review, we summarize development of additive effects in the asymmetric hydrogenation of N-heteroaromatic compounds based on interactions of additives with catalysts and substrates.