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Short Paper | Regular issue | Vol 87, No. 5, 2013, pp.1099-1108
Published online, 26th March, 2013
DOI: 10.3987/COM-13-12690
One-Pot Synthesis of (Guaiazulen-1-yl)furan Derivatives from Guaiazulene and 1,4-Diaryl-2-butene-1,4-diones

Dao-Lin Wang,* Jia-Yi Yu, Jiao Xu,* and Zhe Dong

*Liaoning Key Laboratory of Synthesis and Application of Functional Compound, College of Chemistry & Chemical Engineering, Bohai University, Jinzhou 121001, China

Abstract

A facile, convenient, efficient, and high yielding synthesis of 3-(guaiazulen-1-yl)furan derivatives (3) has been developed by the condensation of guaiazulene (1) with 1,4-diaryl-2-butene-1, 4-diones (2) as nucleophiles in the presence of p-toluenesulfonic acid as the catalyst.