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Paper | Regular issue | Vol 87, No. 5, 2013, pp.1029-1037
Published online, 2nd April, 2013
DOI: 10.3987/COM-13-12691
New Diketopiperazine Derivatives from Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis Lineaus

Amgad I. M. Khedr, Isao Kouno, Takashi Tanaka, and Koji Yamada*

*Graduate school of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki 852-8521, Japan

Abstract

Two new diketopiperazine derivatives, staphyloamides A (1), and B (2), have been isolated from the culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis Lineaus, along with the known cyclo (L-pro-D-phe) (3), cyclo (D-6-Hypro-L-phe) (4), cyclo (L-pro-L-val) (5), cyclo (L-pro-L-phe) (6), cyclo (L-pro-L-tyr) (7), cyclo (L-pro-L-leu) (8), cyclo (L-pro-L-ala) (9), and bacillusamide B (10). These structures were elucidated by extensive spectroscopic methods. Antimicrobial activities of compounds 310 were done.