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Communication | Regular issue | Vol 87, No. 5, 2013, pp.1023-1028
Published online, 5th April, 2013
DOI: 10.3987/COM-13-12697
■ Post-Modification of Triazole-Linked Analogues of DNA for Positively Charged Variants

Tomoko Fujino, Yusuke Miyauchi, Nobuhide Tsunaka, Koudai Okada, and Hiroyuki Isobe*

*Department of Chemistry and Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Aoba-ku, Sendai 980-8578, Japan

Abstract

We report a concise post-modification method to convert an electroneutral triazole-linked DNA (TLDNA) to a positively charged triazolium-linked analogue, TLDNA+. A one-step methylation of oligothymine TLDNA successfully afforded TLDNA+ with a dramatic improvement in the solubility. The pentameric oligothymine TLDNA+ formed a stable triple helix with natural oligoadenine DNA as well as a mercury-mediated self-duplex.