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Paper | Regular issue | Vol 87, No. 5, 2013, pp.1059-1074
Published online, 10th April, 2013
DOI: 10.3987/COM-13-12703
Synthesis and Characterization of 4-Substituted 1-(4-Halogenophenyl)pyrrolidin-2-ones with Azole and Azine Moieties

Rita Vaickelioniene, Vytautas Mickevicius,* and Gema Mikulskiene

*Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, Kaunas LT-50254, Lithuania

Abstract

4-Substituted 1-(4-fluoro- and 4-chlorophenyl)pyrrolidin-2-ones containing azole, oxadiazole, triazole, and triazine fragments have been synthesized, and the characterization of the obtained products is presented. The study compounds have been analyzed by elemental analysis, and the NMR, IR, MS techniques. The 1H/13C 2D (HETCOR), APT (13C) NMR methods, and molecular modeling (MM2) were used for structure elucidation in more complicated cases.