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■ New Xanthones from Garcinia bracteata and Their Cytotoxicities

Qiu-Fen Hu,* Deyun Niu, Xiangli Li, Yunhua Qin, Zongyan Yang, Guoli Zhao, Zhongxiu Yang, Xue-Mei Gao,* and Zhangyu Chen

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China

Abstract

Two new xanthones, bracthones A (1) and B (2), together with four known xanthones (3-6) were isolated from the stems of Garcinia bracteata. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. Compounds 1-6 were tested for their cytotoxicities against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). Compounds 1 and 2 showed high cytotoxicities against PC3 cell with IC50 values of 3.24 and 2.15 μM, respectively.