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Short Paper | Special issue | Vol 88, No. 2, 2014, pp.1661-1666
Published online, 15th November, 2013
DOI: 10.3987/COM-13-S(S)121
Asymmetric Alkylation of α-Cyanosulfones Catalyzed by Chiral 1,2,3-Triazolium Salts

Kohsuke Ohmatsu, Yusuke Hakamata, Ayano Goto, and Takashi Ooi*

*Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya, Aichi 464-8601, Japan

Abstract

Chiral 1,2,3-triazolium salt-catalyzed asymmetric phase-transfer alkylation of α-cyanosulfones has been developed. This protocol is applicable to a variety of benzylic and allylic halides and cyanosulfones, affording chiral sulfones possessing tetrasubstituted carbons in excellent yields with good-to-high enantioselectivities.