Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 87, No. 6, 2013, pp.1349-1358
Published online, 13th May, 2013
DOI: 10.3987/COM-13-12726
A FACILE SYNTHESIS OF (5-HYDROXY-4-OXO-4H-PYRAN-2-YL)METHYL CARBOXYLATES AND THEIR ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS

Tetsuro Shimo,* Yuki Taketsugu, Takuya Goto, Masaaki Toyama, Kohji Yoshimura, and Masanori Baba

*Department of Chemistry, Faculty of Engineering, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan

Abstract

5-Benzyloxy-2-hydroxymethyl-4H-pyran-4-one (2) was synthesized from kojic acid (1) and subsequently reacted with carboxylic anhydride (3a) and a series of carboxylic acid chlorides (3bl) to give the corresponding (5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (4al). These compounds were then reductively debenzylated to afford the (5-hydroxy-4-oxo-4H-pyran-2-yl)methyl carboxylates (5a-l), which were tested for their inhibitory activities against the hepatitis C virus.