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Review | Regular issue | Vol 87, No. 7, 2013, pp.1441-1479
Published online, 24th May, 2013
DOI: 10.3987/REV-13-771
DIHYDROPYRIMIDINE

Hidetsura Cho*

*Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, sendai 980-8578, Japan

Abstract

The synthesis history, physical properties (stability and tautomerism), ring construction procedures, a variety of reactions, various skeletons (monocyclic, bicyclic, tricyclic, tetracyclic, bicyclo-, and spiro-), and biological activities of dihydropyrimidines are reviewed.