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Short Paper | Regular issue | Vol 87, No. 7, 2013, pp.1561-1569
Published online, 30th May, 2013
DOI: 10.3987/COM-13-12738
ent-3,4-seco-Labdane Diterpenoids from Callicarpa nudiflora Leaves with Anti-inflammatory Activity

Lei Zhang, Jian Huang, Mingsheng Liu,* Cui Zhang, Guoyu Li, Ke Zhang, Lin Dong, and Jinhui Wang*

*School of Traditional Chinese Materia Medicine, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang, China

Abstract

Two new ent-3,4-seco-labdane diterpenoids, ent-3,4-seco-16-hydroxy-12,15-epoxy-4(18),8(17),12,14-labdatetraen-3-oic acid (1) and ent-3,4-seco-12R,15-epoxy-4(18),8(17),13-labdatrien-3-oic acid (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by extensive spectroscopic analysis and the biosynthetic pathways leading to these compounds were proposed. The two compounds both exerted potent inhibitory activity against the production of nitric oxide (NO) in RAW264.7 stimulated by lipopolysaccharide (LPS).