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Paper | Regular issue | Vol 87, No. 8, 2013, pp.1699-1710
Published online, 27th June, 2013
DOI: 10.3987/COM-13-12746
Synthesis, Characterization and Suppression of Impurities during Optimization of Dabigatran Etexilate

Yu Chen,* Jun Liang, Huansheng Chen, and Li Yuan

*R&D Department, Shanghai AoBo Bio-pharmaceutical Technology Co., Ltd., Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Shanghai, 201203, China

Abstract

The synthetic methods for two impurities of dabigatran etexilate are firstly described, and both of two impurities are characterized by NMR and MS spectral data. The suppression of impurities as well as the optimization process of dabigatran etexilate is also disclosed.