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Short Paper | Regular issue | Vol 87, No. 8, 2013, pp.1749-1764
Published online, 4th July, 2013
DOI: 10.3987/COM-13-12747
Efficient Synthesis of N-Methylamides and Amines via 4-(Alkylamino)benzyl-N-methylamine as a New Protecting Group

Sang-Hak Lee, Yu Mu, Gun-Woo Kim, Jin-Seok Kim, Seok-Hwi Park, Tian Jin, Kee-Young Lee, and Won-Hun Ham*

*School of Pharmacy, Sungkyunkwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon-Si, Gyeong gi-Do 440-746, Korea

Abstract

4-(Alkylamino)benzyl-N-methylamine is a good protecting group for the synthesis of N-methylamides and amines. The N-debenzylation of N-methylamides and amines can be carried out selectively and efficiently under condition using trifluoroacetic acid (TFA).