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Communication | Special issue | Vol 88, No. 2, 2014, pp.939-944
Published online, 5th August, 2013
DOI: 10.3987/COM-13-S(S)92
Biomimetic Synthesis of Antrodia Maleimides and Maleic Anhydrides

John Boukouvalas* and Vincent Albert

*Pavillon Alexandre-Vachon, Department of Chemistry, Laval University, 1045 Avenue de la Médecine, Quebec City, Quebec G1V 0A6, Canada

Abstract

A simple and efficient biomimetic synthesis of Antrodia maleimides and maleic anhydrides, including the HCV protease inhibitor antrodin A, is described. The key step is a Perkin-type condensation performed under exceptionally mild conditions.