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Short Paper | Regular issue | Vol 87, No. 10, 2013, pp.2053-2069
Published online, 10th September, 2013
DOI: 10.3987/COM-13-12780
Synthesis of Chromeno[2,3-b]indole Derivates

Eszter Gráczol-Fördős, Tibor Novák, Gábor Blaskó, Imre Fejes, François Perron-Sierra, and Miklós Nyerges*

*CHL, Servier Research Institute of Medicinal Chemistry, Záhony utca 7, H-1031 Budapest, Hungary

Abstract

Several new chromeno[2,3-b]indole tetracycles were synthesized by the reaction of 2’-hydroxyacetophenones or 2’-hydroxypropiophenones and salicylaldehyde derivates. Under the harsh reaction conditions, the initially formed Knoevenagel adducts lost water, giving rise to the formation of ring closed tetracyclic products.