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Short Paper | Regular issue | Vol 87, No. 10, 2013, pp.2071-2079
Published online, 12th September, 2013
DOI: 10.3987/COM-13-12785
SYNTHESIS OF 4-METHOXY and 5-METHOXY SUBSTITUTED 7-AZA-ISOINDOLIN-1-ONES

Heng Zhou, Guanglong Sun, Zeng-Lu Liu, Xiao-Ping Zhan, and Zhen-Min Mao*

*School of Pharmacy, Shanghai Jiaotong University , No.800 Dongchuan Road, Minhang District, Shanghai 200240, China

Abstract

A simple and convenient route for the synthesis of a series of 4-methoxy or 5-methoxy substituted 7-aza-isoindolin-1-ones is described. Methoxyl substituted pyridine derivatives were cyclized with different amines under alkaline condition to give the desired products.