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Short Paper | Regular issue | Vol 87, No. 10, 2013, pp.2093-2102
Published online, 28th August, 2013
DOI: 10.3987/COM-13-12797
A MICROWAVE ASSISTED SYNTHESIS OF HIGHLY SUBSTITUTED 7-METHYL-5H-THIAZOLO[3,2-a]PYRIMIDINE-6-CARBOXYLATE DERIVATIVES VIA ONE-POT REACTION OF AMINOTHIAZOLE, ALDEHYDE AND ETHYL ACETOACETATE

Bing Zhao, Li-Li Jiang, Zhuo Liu, Qi-Gang Deng,* Li-Yan Wang, Bo Song, and Yan Gao*

*College of Chemistry and Chemical Engineering, Qiqihar University, 42 Wenhuadajie, Qiqihar, Heilongjian Shang, 161006, China

Abstract

The synthesis of highly substituted 7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives by one-pot reaction of aminothiazole, aldehyde and ethyl acetoacetate under microwave irradiation have been accomplished without any catalyst. This approach provides a simple, rapid, and green method for the synthesis of 7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives.