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Short Paper | Regular issue | Vol 87, No. 10, 2013, pp.2103-2108
Published online, 10th September, 2013
DOI: 10.3987/COM-13-12798
■ Xanthone Derivatives form the Fermentation Products of an Endophytic Fungus of Phomopsis amygdali

Qiufen Hu, Deyun Niu, Shuai Yang, Hongyun Cao, Chunyang Meng, Haiyin Yang, Xuemei Gao,* and Gang Du*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China

Abstract

Two new xanthones, 1,5-dihydroxy-3-(2-oxopropyl)-6-methoxycarbonylxanthone (1) and 1-hydroxy-3-(2-oxopropyl)-8-methoxycarbonyl- xanthone (2), together with four known xanthones (3-6) were isolated from the fermentation products of a Phomopsis fungus. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed high cytotoxicity against A549 and PC3 cell with IC50 values of 3.5 and 2.8 μM. Compound 2 showed high cytotoxicity against PC3 cell with IC50 value of 2.4 μM. The other compounds also showed moderate cytotoxicity for some tested cell lines with IC50 values between 5.2-8.6 μM.