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Review | Special issue | Vol 88, No. 2, 2014, pp.879-897
Published online, 26th September, 2013
DOI: 10.3987/REV-13-SR(S)6
Electrochemical Behaviour of Alkaloids: Detection and Interaction with DNA and Proteins

Martina Zatloukalová, Jan Vacek, and Vilím Šimánek*

*Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hnevotínská 3, 77515 Olomouc, Czech Republic

Abstract

Electroanalysis can provide valuable information on the molecular interactions, biological activity and pharmacological potential of alkaloids. This article summarizes current knowledge on the electrochemical properties of a broad spectrum of alkaloids using polarography and voltammetry. Alkaloid interactions with DNA and proteins using electrochemical techniques are also described. More than 100 references published in the last 70 years are reviewed.