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Review | Regular issue | Vol 89, No. 4, 2014, pp.869-962
Published online, 20th December, 2013
DOI: 10.3987/REV-13-781

Pradip Kumar Maji,* Rafique Ul Islam,* and Sujit Kumar Bera

*Department of Chemistry, Bidhan Chandra College , Asansol, Burdwan, 713304, WB, India


This review highlights some remarkable recently made achievements in the application of metal-catalyzed processes to the design of Multicomponent syntheses of Heterocycles. The domino MCRs that are purely based upon metal catalysis opens a vast field for the discovery of new sequences in heterocyclic synthesis. Many of these methods have proven to be the most powerful and are currently applied in target- or diversity-oriented syntheses. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy and manpower. Moreover, the reaction period can be substantially shortened. This review article aims at reporting the recent developments devoted to this important area, focusing on the metal catalysis in Multicomponent synthesis of heterocycles.